Article
Pharmacogenetic interactions between beta-blocker therapy and the angiotensin-converting enzyme deletion polymorphism in patients with congestive heart failure.
Circulation - 27 Mar 2001
McNamara D M, Holubkov R, Janosko K, Palmer A, Wang J J, MacGowan G A, Murali S, Rosenblum W D, London B, Feldman A M
Abstract excerpt
BACKGROUND: Activation of the renin-angiotensin and sympathetic nervous systems adversely affect heart failure progression. The ACE deletion allele (ACE D) is associated with increased renin-angiotensin activation; however, its influence on patient outcomes remains uncertain, and the pharmacogene...
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