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Clinically Relevant Circulating Protein Biomarkers for Type 1 Diabetes: Evidence From a Two-Sample Mendelian Randomization Study.

Diabetes care - 1 Jan 2022

Yazdanpanah Nahid, Yazdanpanah Mojgan, Wang Ye, Forgetta Vincenzo, Pollak Michael, Polychronakos Constantin, Richards J Brent, Manousaki Despoina

Abstract excerpt

OBJECTIVE: To identify circulating proteins influencing type 1 diabetes susceptibility using Mendelian randomization (MR). RESEARCH DESIGN AND METHODS: We used a large-scale two-sample MR study, using cis genetic determinants (protein quantitative trait loci [pQTL]) of up to 1,611 circulating proteins from five large genome-wide association studies, to screen for causal associations of these proteins with type 1...

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PMID: 34758976
DOI: 10.2337/dc21-1049

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