Article
Ghrelin receptor gene: identification of several sequence variants in extremely obese children and adolescents, healthy normal-weight and underweight students, and children with short normal stature.
The Journal of clinical endocrinology and metabolism - 1 Jan 2004
Wang Hai-Jun, Geller Frank, Dempfle Astrid, Schäuble Nadine, Friedel Susann, Lichtner Peter, Fontenla-Horro Francisco, Wudy Stefan, Hagemann Sandra, Gortner Ludwig, Huse Klaus, Remschmidt Helmut, Bettecken Thomas, Meitinger Thomas, Schäfer Helmut, Hebebrand Johannes, Hinney Anke
Abstract excerpt
GH secretagogue receptor (GHSR, ghrelin receptor) is involved in regulation of body weight and GH secretion. We initially analyzed two single-nucleotide polymorphisms of the GHSR in up to 184 extremely obese children and adolescents and up to 184 healthy underweight students. The frequency of the 171T allele of rs495225 was higher in our obese samples (75.0%) than in the underweight individuals (70.2%; nominal P...
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