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Article

Role of the chemokine decoy receptor D6 in balancing inflammation, immune activation, and antimicrobial resistance in Mycobacterium tuberculosis infection.

The Journal of experimental medicine - 1 Sept 2008

Di Liberto Diana, Locati Massimo, Caccamo Nadia, Vecchi Annunciata, Meraviglia Serena, Salerno Alfredo, Sireci Guido, Nebuloni Manuela, Caceres Neus, Cardona Pere-Joan, Dieli Francesco, Mantovani Alberto

Abstract excerpt

D6 is a decoy and scavenger receptor for inflammatory CC chemokines. D6-deficient mice were rapidly killed by intranasal administration of low doses of Mycobacterium tuberculosis. The death of D6(-/-) mice was associated with a dramatic local and systemic inflammatory response with levels of M. tuberculosis colony-forming units similar to control D6-proficient mice. D6-deficient mice showed an increased numbers...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18695004
DOI: 10.1084/jem.20070608
PMCID: PMC2526202

Genes

CCL2
CCL3
CCL4
CCL5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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