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Article

[TMPRSS2-ETS gene fusion in prostate cancer].

Der Urologe. Ausg. A - 1 Jul 2007

Perner S, Schmidt F H, Hofer M D, Kuefer R, Rubin M

Abstract excerpt

BACKGROUND: Recurrent chromosomal rearrangements have not been well characterized in common carcinomas. Using a novel bioinformatics approach, our group recently described a novel gene fusion in PCa. This fusion involves the androgen-regulated gene TMPRSS2 and so far three members of the ETS family of transcription factors already described as rearranged in the Ewing's family of tumors. By analogy, fusion status...

Topics

Biomarkers, Tumor
Genetic Predisposition to Disease
Humans
Male
Neoplasm Proteins
Oncogene Fusion
Prevalence
Prostatic Neoplasms
Proto-Oncogene Proteins c-ets
Serine Endopeptidases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 17458530
DOI: 10.1007/s00120-007-1347-0

Genes

TMPRSS2
ERG
ETV1
ETV4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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