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Article

Selective pressure on a saccharin intake phenotype and its correlates: a replication study.

Chemical senses - 1 Jan 2023

Dess Nancy K, Chapman Clinton D, Jacobi Paulina M

Abstract excerpt

The Occidental High- and Low-Saccharin rats (respectively, HiS and LoS lines) were selectively bred for decades to examine mechanisms and correlates of a saccharin intake phenotype. Observed line differences ranged from taste and eating to drug self-administration and defensive behavior, paralleling human research on relationships between gustation, personality, and psychopathology. The original lines were...

Topics

Humans
Rats
Animals
Saccharin
Quinine
Sodium Chloride
Phenotype
Sucrose
Taste

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 37387468
DOI: 10.1093/chemse/bjad021

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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