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Article

A basic cluster determines topology of the cytoplasmic M3-M4 loop of the glycine receptor alpha1 subunit.

The Journal of biological chemistry - 9 May 2003

Sadtler Sven, Laube Bodo, Lashub Alhassan, Nicke Annette, Betz Heinrich, Schmalzing Günther

Abstract excerpt

The inhibitory glycine receptor is a member of the ligand-gated ion channel superfamily of neurotransmitter receptors, which are composed of homologous subunits with four transmembrane segments (M1-M4), each. Here, we demonstrate that the correct topology of the glycine receptor alpha1 subunit depends critically on six positively charged residues within a basic cluster, RFRRKRR, located in the large cytoplasmic...

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PMID: 12611885
DOI: 10.1074/jbc.M213077200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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