Article
Isolation and characterization of invasive and noninvasive variants of a rat bladder tumor cell line.
Japanese journal of cancer research : Gann - 1 Sept 1997
Nishi N, Inui M, Kishi Y, Miyanaka H, Wada F
Abstract excerpt
We isolated, in vitro, spontaneous variants of the rat bladder tumor NBT-II cell line with a distinctive morphology. Of five sublines obtained, three (NBT-L1, L2a and L2b) exhibited an elongated shape and moderate to high invasive activity in vitro. The other two sublines (NBT-T1 and T2) formed tight colonies and exhibited very low or negligible invasive activity. The contents of mRNAs coding for E-cadherin and...
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