Article

The structure of a calsequestrin filament reveals mechanisms of familial arrhythmia

2019-06-15

Abstract excerpt

Mutations in the calcium-binding protein calsequestrin cause a highly lethal familial arrhythmia, catecholaminergic polymorphic ventricular tachycardia (CPVT). In vivo, calsequestrin multimerizes into filaments, but a compelling atomic-resolution structure of a calsequestrin filament is lacking. We report a crystal structure of a cardiac calsequestrin filament with supporting mutation analysis provided by an in v...

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Literature Corpus work: 2b17f581-3731-5ff6-bc94-74ab290dc60d
DOI: 10.1101/672303

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