Article
Calcium site mutations in cadherin: impact on adhesion and evidence of cooperativity.
Biochemistry - 6 Jun 2006
Prakasam A, Chien Y-H, Maruthamuthu V, Leckband D E
Abstract excerpt
This work describes quantitative force and bead aggregation measurements of the adhesion and binding mechanisms of canine E-cadherin mutants W2A, D134A, D103A, D216A, D325A, and D436A. The W2A mutation affects the formation of the N-terminal strand dimer, and the remaining mutations target calcium binding sites at the interdomain junctions. Surface force measurements show that the full ectodomain of canine...
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