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Article

CTLA-4 +49A>G polymorphism is associated with the risk but not with the progression of colorectal cancer in Chinese.

International journal of colorectal disease - 1 Jan 2010

Qi Peng, Ruan Can-ping, Wang Hao, Zhou Fei-guo, Xu Xin-yun, Gu Xing, Zhao Yun-peng, Dou Tong-hai, Gao Chun-fang

Abstract excerpt

PURPOSE: Colorectal cancer (CRC) is one of the most common malignancies in the world and a multipathway disease. Cytotoxic T-lymphocyte antigen-4 (CTLA-4) is a potent immunoregulatory molecule that suppresses antitumor response by down-regulating T-cell activation. The most studied +49A>G polymorphism of CTLA-4 gene has been associated with several autoimmune or cancer diseases. Our aim was to investigate the...

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Antigens, CD
Asian People
Case-Control Studies
China
Colorectal Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Disease Progression

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PMID: 19787358
DOI: 10.1007/s00384-009-0806-z

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