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Article

The effect of rearing experience and TPH2 genotype on HPA axis function and aggression in rhesus monkeys: a retrospective analysis.

Hormones and behavior - 1 Feb 2010

Chen Guo-Lin, Novak Melinda A, Meyer Jerrold S, Kelly Brian J, Vallender Eric J, Miller Gregory M

Abstract excerpt

Gene-environment (GxE) interactions contribute to the development of many neuropsychiatric disorders. Tryptophan hydroxylase-2 (TPH2) synthesizes neuronal serotonin and is closely related to the hypothalamic-pituitary-adrenal (HPA) axis, while early life experience is a critical environmental factor programming the HPA axis response to stress. This retrospective study investigated GxE interaction at the TPH2...

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Source

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Identifiers

PMID: 19900455
DOI: 10.1016/j.yhbeh.2009.10.012
PMCID: PMC2815197

Genes

TPH2
CRH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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