Article
Laminin-511 is an epithelial message promoting dermal papilla development and function during early hair morphogenesis.
Genes & development - 1 Aug 2008
Gao Jing, DeRouen Mindy C, Chen Chih-Hsin, Nguyen Michael, Nguyen Ngon T, Ido Hiroyuki, Harada Kenji, Sekiguchi Kiyotoshi, Morgan Bruce A, Miner Jeffery H, Oro Anthony E, Marinkovich M Peter
Abstract excerpt
Hair morphogenesis takes place through reciprocal epithelial and mesenchymal signaling; however, the mechanisms controlling signal exchange are poorly understood. Laminins are extracellular proteins that play critical roles in adhesion and signaling. Here we demonstrate the mechanism of how laminin-511 controls hair morphogenesis. Dermal papilla (DP) from laminin-511 mutants showed developmental defects by E16.5,...
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