Article
Drosophila laminins act as key regulators of basement membrane assembly and morphogenesis.
Development (Cambridge, England) - 1 Dec 2009
Urbano Jose M, Torgler Catherine N, Molnar Cristina, Tepass Ulrich, López-Varea Ana, Brown Nicholas H, de Celis Jose F, Martín-Bermudo Maria D
Abstract excerpt
Laminins are heterotrimeric molecules found in all basement membranes. In mammals, they have been involved in diverse developmental processes, from gastrulation to tissue maintenance. The Drosophila genome encodes two laminin alpha chains, one beta and one Gamma, which form two distinct laminin trimers. So far, only mutations affecting one or other trimer have been analysed. In order to study embryonic...
Topics
- Animals
- Basement Membrane
- Cell Adhesion
- Cell Movement
- Collagen Type IV
- Drosophila
- Drosophila Proteins
- Embryo, Nonmammalian
- Heparan Sulfate Proteoglycans
- Laminin
- Morphogenesis