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Article

Functional deficits in PAK5, PAK6 and PAK5/PAK6 knockout mice.

PloS one - 1 Jan 2013

Furnari Melody A, Jobes Michelle L, Nekrasova Tanya, Minden Audrey, Wagner George C

Abstract excerpt

The p21-activated kinases are effector proteins for Rho-family GTPases. PAK4, PAK5, and PAK6 are the group II PAKs associated with neurite outgrowth, filopodia formation, and cell survival. Pak4 knockout mice are embryonic lethal, while Pak5, Pak6, and Pak5/Pak6 double knockout mice are viable and fertile. Our previous work found that the double knockout mice exhibit locomotor changes and learning and memory...

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Source

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Identifiers

PMID: 23593460
DOI: 10.1371/journal.pone.0061321
PMCID: PMC3620390

Genes

PAK5
PAK6
PAK4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Functional deficits in PAK5, PAK6 and PAK5/PAK6 knockout mice.PMID 23593460Read ↗

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