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Article

GTPase activity is not essential for the interferon-inducible MxA protein to inhibit the replication of hepatitis B virus.

Archives of virology - 1 Jan 2008

Yu Zhijian, Wang Zhanhui, Chen Jinjun, Li Hui, Lin Zhanzhou, Zhang Fan, Zhou Yuanping, Hou Jinlin

Abstract excerpt

Multiple studies have established that GTPase activity is critical for MxA to act against RNA viruses. Recently, it was shown that MxA can also restrict the replication of hepatitis B virus (HBV), a DNA virus, but the requirements for GTPase activity in inhibition of HBV by MxA remain unknown. Here, we report that GTPase-defective mutants (K83A, T103A, and L612K) can downregulate extracellular HBsAg and HBeAg and...

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Source

Identifiers

PMID: 18668195
DOI: 10.1007/s00705-008-0168-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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