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Article

Dominant-negative mutants of human MxA protein: domains in the carboxy-terminal moiety are important for oligomerization and antiviral activity.

Journal of virology - 1 Apr 1997

Ponten A, Sick C, Weeber M, Haller O, Kochs G

Abstract excerpt

Human MxA protein is an interferon-induced 76-kDa GTPase that exhibits antiviral activity against several RNA viruses. Wild-type MxA accumulates in the cytoplasm of cells. TMxA, a modified form of wild-type MxA carrying a foreign nuclear localization signal, accumulates in the cell nucleus. Here we show that MxA protein is translocated into the nucleus together with TMxA when both proteins are expressed...

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Identifiers

PMID: 9060610
DOI: 10.1128/JVI.71.4.2591-2599.1997
PMCID: PMC191379

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Source receipt: pubmed, retrieved 7 Sept 2026.

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