Article
Dominant-negative mutants of human MxA protein: domains in the carboxy-terminal moiety are important for oligomerization and antiviral activity.
Journal of virology - 1 Apr 1997
Ponten A, Sick C, Weeber M, Haller O, Kochs G
Abstract excerpt
Human MxA protein is an interferon-induced 76-kDa GTPase that exhibits antiviral activity against several RNA viruses. Wild-type MxA accumulates in the cytoplasm of cells. TMxA, a modified form of wild-type MxA carrying a foreign nuclear localization signal, accumulates in the cell nucleus. Here...
Topics
- 3T3 Cells
- Animals
- Antigens, Viral
- Antiviral Agents
- Binding Sites
- Chlorocebus aethiops
- GTP-Binding Proteins
- Genes, Dominant
- Humans
- Influenza A virus
- Mice
- Mutagenesis
- Mutation
- Myxovirus Resistance Proteins
- Nucleocapsid
- Proteins
- RNA, Viral
- Recombinant Fusion Proteins