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Article

A monomeric GTPase-negative MxA mutant with antiviral activity.

Journal of virology - 1 Sept 2000

Janzen C, Kochs G, Haller O

Abstract excerpt

MxA is a large, interferon-induced GTPase with antiviral activity against RNA viruses. It forms large oligomers, but whether oligomerization and GTPase activity are important for antiviral function is not known. The mutant protein MxA(L612K) carries a lysine-for-leucine substitution at position 612 and fails to form oligomers. Here we show that monomeric MxA(L612K) lacks detectable GTPase activity but is capable...

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Identifiers

PMID: 10933733
DOI: 10.1128/jvi.74.17.8202-8206.2000
PMCID: PMC112356

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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