Article
Significance of the myxovirus resistance A (MxA) gene -123C>a single-nucleotide polymorphism in suppressed interferon beta induction of severe acute respiratory syndrome coronavirus infection.
The Journal of infectious diseases - 15 Jun 2010
Ching Johannes Chi-Yun, Chan Kelvin Yuen Kwong, Lee Eric Hing Leung, Xu Mei-Shu, Ting Campbell Kam Po, So Thomas M K, Sham Pak C, Leung Gabriel M, Peiris Joseph S M, Khoo Ui-Soon
Abstract excerpt
Myxovirus resistance A (MxA) is an antiviral protein induced by interferon alpha and beta (IFN-alpha, IFN-beta) that can inhibit viral replication. The minor alleles of the -88G>T and -123C>A MxA promoter single-nucleotide polymorphisms (SNPs) are associated with increased promoter activity and altered response to IFN-alpha and IFN-beta treatment. Here, we demonstrate that the -123A minor allele provided stronger...
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