Article
A functional polymorphism of the vasoactive intestinal peptide receptor 1 gene correlates with the presence of HLA-B*2705 in Sardinia.
Genes and immunity - 1 Dec 2008
Paladini F, Cocco E, Cauli A, Cascino I, Vacca A, Belfiore F, Fiorillo M T, Mathieu A, Sorrentino R
Abstract excerpt
The association of HLA-B27 with ankylosing spondylitis (AS) is the strongest among all inflammatory diseases. However, the exact role of these molecules in disease pathogenesis is still unknown. The existence of HLA-B27 variants rarely found in patients introduces a further level of complexity. It is now accepted that other genes of minor impact contribute to modify disease susceptibility and these genes might be...
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