Article
Genetic association of vasoactive intestinal peptide receptor with rheumatoid arthritis: altered expression and signal in immune cells.
Arthritis and rheumatism - 1 Apr 2008
Delgado Mario, Robledo Gema, Rueda Blanca, Varela Nieves, O'Valle Francisco, Hernandez-Cortes Pedro, Caro Marta, Orozco Gisela, Gonzalez-Rey Elena, Martin Javier
Abstract excerpt
OBJECTIVE: Vasoactive intestinal peptide (VIP) has been shown to be one of the endogenous factors involved in the maintenance of immune tolerance. Administration of VIP ameliorates clinical signs in various experimental autoimmune disorders. This study was undertaken to investigate whether the exacerbated inflammatory autoimmune response in rheumatoid arthritis (RA) might result directly from altered expression...
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