Mutant SOD1 instability: implications for toxicity in amyotrophic lateral sclerosis.

doi:10.1159/000089616

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Article

Mutant SOD1 instability: implications for toxicity in amyotrophic lateral sclerosis.

Neuro-degenerative diseases - 1 Jan 2005

Tiwari Ashutosh, Hayward Lawrence J

Abstract excerpt

The biological basis of preferential motor neuron degeneration in amyotrophic lateral sclerosis (ALS) remains incompletely understood, and effective therapies to prevent the lethal consequences of this disorder are not yet available. Since 1993, more than 100 mutant variants of the antioxidant enzyme Cu/Zn superoxide dismutase (SOD1) have been identified in familial ALS. Many studies have sought to distinguish...

Topics

Amyotrophic Lateral Sclerosis
Animals
Humans
Mutation
Protein Structure, Quaternary
Superoxide Dismutase
Superoxide Dismutase-1

Source

Open in PubMed

Identifiers

PMID: 16909016
DOI: 10.1159/000089616

Genes

SOD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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