Article
Glutathione S-transferase m1 and t1 null genotypes increase susceptibility to idiosyncratic drug-induced liver injury.
Hepatology (Baltimore, Md.) - 1 Aug 2008
Lucena M Isabel, Andrade Raúl J, Martínez Carmen, Ulzurrun Eugenia, García-Martín Elena, Borraz Yolanda, Fernández M Carmen, Romero-Gomez Manuel, Castiella Agustin, Planas Ramón, Costa Joan, Anzola Sandra, Agúndez José A G
Abstract excerpt
UNLABELLED: Individual vulnerability to drug-induced liver injury (DILI) might result from deficiencies in the detoxification process, which determines the level of exposure to the reactive metabolite. We evaluated whether a genetically determined reduction in the ability to detoxify electrophilic compounds, such as that expected among individuals with glutathione S-transferase (GST) null genotypes, might play a...
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