Article
Mitochondrial superoxide dismutase and glutathione peroxidase in idiosyncratic drug-induced liver injury.
Hepatology (Baltimore, Md.) - 1 Jul 2010
Lucena M Isabel, García-Martín Elena, Andrade Raúl J, Martínez Carmen, Stephens Camilla, Ruiz Jhon D, Ulzurrun Eugenia, Fernandez M Carmen, Romero-Gomez Manuel, Castiella Augustin, Planas Ramon, Durán José Antonio, De Dios Ana Melcón, Guarner Carlos, Soriano German, Borraz Yolanda, Agundez José A G
Abstract excerpt
UNLABELLED: Drug-induced liver injury (DILI) susceptibility has a potential genetic basis. We have evaluated possible associations between the risk of developing DILI and common genetic variants of the manganese superoxide dismutase (SOD2 Val16Ala) and glutathione peroxidase (GPX1 Pro200Leu) genes, which are involved in mitochondrial oxidative stress management. Genomic DNA from 185 DILI patients assessed by the...
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