Article
Expression of recombination activating genes in germinal center B cells: involvement of interleukin 7 (IL-7) and the IL-7 receptor.
The Journal of experimental medicine - 20 Jul 1998
Hikida M, Nakayama Y, Yamashita Y, Kumazawa Y, Nishikawa S I, Ohmori H
Abstract excerpt
Mouse germinal center (GC) B cells have been shown to undergo secondary V(D)J (V, variable; D, diversity; J, joining) recombination (receptor editing) mediated by the reexpressed products of recombination activating gene (RAG)-1 and RAG-2. We show here that interleukin (IL)-7 as well as IL-4 was...
Topics
- Animals
- Antigens, CD
- B-Lymphocytes
- Cell Differentiation
- Gene Expression Regulation
- Genetic Variation
- Germinal Center
- Interleukin-7
- Mice
- Receptors, Interleukin
- Receptors, Interleukin-7
- Recombination, Genetic