Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Epigenetic deregulation of multiple S100 gene family members by differential hypomethylation and hypermethylation events in medulloblastoma

19 Jun 2007

Abstract excerpt

Deregulated expression of genes encoding members of the S100 family of calcium-binding proteins has been associated with the malignant progression of multiple tumour types. Using a pharmacological expression reactivation approach, we screened 16 S100 genes for evidence of epigenetic regulation in medulloblastoma, the most common malignant brain tumour of childhood. Four family members (S100A2, S100A4, S100A6 and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Neonatal Respiratory Health Research
Share to S100 Proteins and Annexins
Share to Traumatic Brain Injury and Neurovascular Disturbances

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 17579622
DOI: 10.1038/sj.bjc.6603852

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Epigenetic deregulation of multiple S100 gene family members by differential hypomethylation and hypermethylation events in medulloblastomaPMID 17579622Read ↗

Global analysis of the medulloblastoma epigenome identifies disease-subgroup-specific inactivation of COL1A2Semantic proximity Read ↗

Increased Efficacy of Histone Methyltransferase G9a Inhibitors Against MYCN-Amplified NeuroblastomaSemantic proximity Read ↗

Increased efficacy of histone methyltransferase G9a inhibitors against MYCN-amplified NeuroblastomaSemantic proximity Read ↗

Epigenetic regulation in medulloblastomaSemantic proximity Read ↗

Tacedinaline (CI-994), a class I HDAC inhibitor, targets intrinsic tumor growth and leptomeningeal dissemination in MYC-driven medulloblastoma while making them susceptible to anti-CD47-induced macrophage phagocytosis via NF-kB-TGM2 driven tumor inflammationSemantic proximity Read ↗

Robust molecular subgrouping and copy-number profiling of medulloblastoma from small amounts of archival tumour material using high-density DNA methylation arraysSemantic proximity Read ↗

Epigenetic inactivation ofMCJ (DNAJD1) in malignant paediatric brain tumoursSemantic proximity Read ↗

Epigenetic inactivation of the RASSF10 candidate tumor suppressor gene is a frequent and an early event in gliomagenesis.Semantic proximity Read ↗

A CTNNB1-altered medulloblastoma shows the immunophenotypic, DNA methylation and transcriptomic profiles of SHH-activated, and not WNT-activated, medulloblastoma.Semantic proximity Read ↗

Ezh2 Delays Activation of Differentiation Genes During Normal Cerebellar Granule Neuron Development and in MedulloblastomaSemantic proximity Read ↗

Ubiquitous aberrant RASSF1A promoter methylation in childhood neoplasia.Semantic proximity Read ↗

The calcium-sensing receptor is silenced by genetic and epigenetic mechanisms in unfavorable neuroblastomas and its reactivation induces ERK1/2-dependent apoptosisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.