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Article

AML with mutated NPM1 carrying a normal or aberrant karyotype show overlapping biologic, pathologic, immunophenotypic, and prognostic features.

Blood - 1 Oct 2009

Haferlach Claudia, Mecucci Cristina, Schnittger Susanne, Kohlmann Alexander, Mancini Marco, Cuneo Antonio, Testoni Nicoletta, Rege-Cambrin Giovanna, Santucci Antonella, Vignetti Marco, Fazi Paola, Martelli Maria Paola, Haferlach Torsten, Falini Brunangelo

Abstract excerpt

Acute myeloid leukemia (AML) with mutated NPM1 usually carries normal karyotype (NK), but it may harbor chromosomal aberrations whose significance remains unclear. We addressed this question in 631 AML patients with mutated/cytoplasmic NPM1. An abnormal karyotype (AK) was present in 93 of 631 cases (14.7%), the most frequent abnormalities being +8, +4, -Y, del(9q), +21. Chromosome aberrations in NPM1-mutated AML...

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Share to Antigens, CD34
Share to Chromosome Aberrations

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to fms-Like Tyrosine Kinase 3

Share to Gene Expression Regulation, Leukemic

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Share to Leukemia, Myeloid, Acute

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Source

Identifiers

PMID: 19429869
DOI: 10.1182/blood-2009-01-197871

Genes

NPM1
FLT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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