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Article

Interference with p53 functions in human viral infections, a target for novel antiviral strategies?

1 Jul 2011

Abstract excerpt

Viral infections cause a major stress in host cells. The cellular responses to stress are mediated by p53, which by deregulation of cell cycle and apoptosis, may also be part of the host cell reaction to fight infections. Therefore, during evolutionary viral adaptation to host organisms, viruses have developed strategies to manipulate host cell p53 dependent pathways to facilitate their viral life cycles. Thus,...

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PMID: 21726011
DOI: 10.1002/rmv.696

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