Neurofibrillary tau pathology modulated by genetic variation of alpha-synuclein.

doi:10.1002/ana.21446

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Neurofibrillary tau pathology modulated by genetic variation of alpha-synuclein.

Annals of neurology - 1 Sept 2008

Peuralinna Terhi, Oinas Minna, Polvikoski Tuomo, Paetau Anders, Sulkava Raimo, Niinistö Leena, Kalimo Hannu, Hernandez Dena, Hardy John, Singleton Andrew, Tienari Pentti J, Myllykangas Liisa

Abstract excerpt

We analyzed whether genetic variation of alpha-synuclein modulates the extent of neuropathological changes in a population-based autopsied sample of 272 elderly Finns. None of the 11 markers was associated with the extent of neocortical beta-amyloid pathology. The intron 4 marker rs2572324 was associated with the extent of neurofibrillary pathology (p = 0.0006, permuted p = 0.004; Braak stages IV-VI vs 0-II). The...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to alpha-Synuclein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lewy Bodies

Share to Neocortex

Share to Nerve Degeneration

Share to Neurodegenerative Diseases

Share to Neurofibrillary Tangles

Share to Neurons

Share to tau Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 18661559
DOI: 10.1002/ana.21446
PMCID: PMC8957216

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 8 closest

Neurofibrillary tau pathology modulated by genetic variation of alpha-synuclein.PMID 18661559Read ↗

APOE and AβPP gene variation in cortical and cerebrovascular amyloid-β pathology and Alzheimer's disease: a population-based analysis.Semantic proximity Read ↗

Alpha-synuclein deposition patterns in Alzheimer’s disease: association with cortical amyloid beta and variable tau loadSemantic proximity Read ↗

Variability in the type and layer distribution of cortical Aβ pathology in familial Alzheimer's disease.Semantic proximity Read ↗

A Multi-Locus and Machine Learning-Based Assessment of SNCA Variants in Alzheimer's Disease.Semantic proximity Read ↗

Genetic association between Alzheimer disease and the alpha-synuclein gene.Semantic proximity Read ↗

An evaluation of the impact of MAPT, SNCA and APOE on the burden of Alzheimer's and Lewy body pathology.Semantic proximity Read ↗

Genetic risk for Alzheimer’s disease influences neuropathology and cognition via multiple biological pathwaysSemantic proximity Read ↗

Neuropathological and genetic correlates of survival and dementia onset in synucleinopathies: a retrospective analysis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.