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Article

A Multi-Locus and Machine Learning-Based Assessment of SNCA Variants in Alzheimer's Disease.

International journal of molecular sciences - 5 Jun 2026

Segmen Hatice, Yildiz Mustafa

Abstract excerpt

This study investigates the role of single nucleotide polymorphisms (SNPs) in the SNCA gene, encoding alpha-synuclein, in Alzheimer's disease (AD). A case-control study was conducted including 95 AD patients and 97 healthy controls. Four SNCA polymorphisms (rs2583988, rs2619363, rs2619364, rs10005233) were analyzed using logistic regression, haplotype estimation, genotype combination analysis, and Random Forest...

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Source

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Identifiers

PMID: 42278664
DOI: 10.3390/ijms27115143
PMCID: PMC13257032

Genes

SNCA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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