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Article

Common genetic variation in multiple metabolic pathways influences susceptibility to low HDL-cholesterol and coronary heart disease.

Journal of lipid research - 1 Dec 2010

Peloso Gina M, Demissie Serkalem, Collins Dorothea, Mirel Daniel B, Gabriel Stacey B, Cupples L Adrienne, Robins Sander J, Schaefer Ernst J, Brousseau Margaret E

Abstract excerpt

A low level of HDL-C is the most common plasma lipid abnormality observed in men with established coronary heart disease (CHD). To identify allelic variants associated with susceptibility to low HDL-C and CHD, we examined 60 candidate genes with key roles in HDL metabolism, insulin resistance, and inflammation using samples from the Veterans Affairs HDL Intervention Trial (VA-HIT; cases, n = 699) and the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20855565
DOI: 10.1194/jlr.P008268
PMCID: PMC2975725

Genes

CUBN
RXRA
SELP
ABCA1
ABCC6
APOA2
APOC4
CETP
FOS
LIPC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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