Article
The RGS protein Crg2 regulates pheromone and cyclic AMP signaling in Cryptococcus neoformans.
Eukaryotic cell - 1 Sept 2008
Shen Gui, Wang Yan-Li, Whittington Amy, Li Lie, Wang Ping
Abstract excerpt
Crg1 and Crg2 are regulators of G-protein signaling homologs found in the human fungal pathogen Cryptococcus neoformans. Crg1 negatively regulates pheromone responses and mating through direct inhibition of Galpha subunits Gpa2 and Gpa3. It has also been proposed that Crg2 has a role in mating, as genetic crosses involving Deltacrg2 mutants resulted in formation of hyperfilaments. We found that mutation of Gpa2...
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