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Canonical Heterotrimeric G Proteins Regulating Mating and Virulence ofCryptococcus neoformans

16 Aug 2007

Abstract excerpt

Perturbation of pheromone signaling modulates not only mating but also virulence in Cryptococcus neoformans, an opportunistic human pathogen known to encode three Galpha, one Gbeta, and two Ggamma subunit proteins. We have found that Galphas Gpa2 and Gpa3 exhibit shared and distinct roles in regulating pheromone responses and mating. Gpa2 interacted with the pheromone receptor homolog Ste3alpha, Gbeta subunit...

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PMID: 17699592
DOI: 10.1091/mbc.e07-02-0136

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