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Article

Mutation of the regulator of G protein signaling Crg1 increases virulence in Cryptococcus neoformans.

Eukaryotic cell - 1 Aug 2004

Wang Ping, Cutler Jim, King Jill, Palmer Daniel

Abstract excerpt

The regulator of G protein signaling homolog Crg1 was found to be a key regulator of pheromone-responsive mating in the opportunistic human fungal pathogen Cryptococcus neoformans. A mutation in the CRG1 gene has greatly increased virulence in the prevalently distributed MATalpha strains of the fungus. Mouse survival time was shortened by 40%, and the lethal dosage was 100-fold less than that of wild-type...

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Identifiers

PMID: 15302835
DOI: 10.1128/EC.3.4.1028-1035.2004
PMCID: PMC500888

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Mutation of the regulator of G protein signaling Crg1 increases virulence in Cryptococcus neoformans.PMID 15302835Read ↗

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Molecular analysis of CPRalpha, a MATalpha-specific pheromone receptor gene of Cryptococcus neoformans.Semantic proximity Read ↗

Gib2, A Novel Gβ-like/RACK1 Homolog, Functions as a Gβ Subunit in cAMP Signaling and Is Essential in Cryptococcus neoformansSemantic proximity Read ↗

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