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Article

Noncanonical Gβ Gib2 is a scaffolding protein promoting cAMP signaling through functions of Ras1 and Cac1 proteins in Cryptococcus neoformans.

The Journal of biological chemistry - 2 May 2014

Wang Yanli, Shen Gui, Gong Jinjun, Shen Danyu, Whittington Amy, Qing Jiang, Treloar Joshua, Boisvert Scott, Zhang Zhengguang, Yang Cai, Wang Ping

Abstract excerpt

Gβ-like/RACK1 functions as a key mediator of various pathways and contributes to numerous cellular functions in eukaryotic organisms. In the pathogenic fungus Cryptococcus neoformans, noncanonical Gβ Gib2 promotes cAMP signaling in cells lacking normal Gpa1 function while displaying versatility in interactions with Gα Gpa1, protein kinase Pkc1, and endocytic intersectin Cin1. To elucidate the Gib2 functional...

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Source

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Identifiers

PMID: 24659785
DOI: 10.1074/jbc.M113.537183
PMCID: PMC4007421

Genes

RACK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Noncanonical Gβ Gib2 is a scaffolding protein promoting cAMP signaling through functions of Ras1 and Cac1 proteins in Cryptococcus neoformans.PMID 24659785Read ↗

Gib2, A Novel Gβ-like/RACK1 Homolog, Functions as a Gβ Subunit in cAMP Signaling and Is Essential in Cryptococcus neoformansSemantic proximity Read ↗

Adenylyl cyclase functions downstream of the Galpha protein Gpa1 and controls mating and pathogenicity of Cryptococcus neoformans.Semantic proximity Read ↗

Canonical Heterotrimeric G Proteins Regulating Mating and Virulence ofCryptococcus neoformansSemantic proximity Read ↗

The RGS protein Crg2 regulates pheromone and cyclic AMP signaling in Cryptococcus neoformans.Semantic proximity Read ↗

The git5 Gbeta and git11 Ggamma form an atypical Gbetagamma dimer acting in the fission yeast glucose/cAMP pathway.Semantic proximity Read ↗

Adenylyl cyclase-associated protein Aca1 regulates virulence and differentiation of Cryptococcus neoformans via the cyclic AMP-protein kinase A cascade.Semantic proximity Read ↗

Direct activation of fission yeast adenylate cyclase by the Gpa2 Galpha of the glucose signaling pathway.Semantic proximity Read ↗

The RGS protein Crg2 regulates both pheromone and cAMP signalling in <i>Cryptococcus neoformans</i>Semantic proximity Read ↗

Glucose repression of fbp1 transcription of Schizosaccharomyces pombe is partially regulated by adenylate cyclase activation by a G protein alpha subunit encoded by gpa2 (git8).Semantic proximity Read ↗

Cryptococcus neoformans mating and virulence are regulated by the G-protein alpha subunit GPA1 and cAMP.Semantic proximity Read ↗

Comparative transcriptome analysis reveals novel roles of the Ras and cyclic AMP signaling pathways in environmental stress response and antifungal drug sensitivity in Cryptococcus neoformans.Semantic proximity Read ↗

Deciphering the regulatory mechanisms of the cAMP/protein kinase A pathway and their roles in the pathogenicity of Candida aurisSemantic proximity Read ↗

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