Article
Metabolomic profiling of Drosophila using liquid chromatography Fourier transform mass spectrometry.
FEBS letters - 20 Aug 2008
Kamleh M A, Hobani Y, Dow J A T, Watson D G
Abstract excerpt
Hydrophilic interaction chromatography (HILIC) interfaced with an Orbitrap Fourier transform mass spectrometer (FT-MS) was used to carry out metabolomic profiling of the classical Drosophila mutation, rosy (ry). This gene encodes a xanthine oxidase/dehydrogenase. In addition to validating the technology by detecting the same changes in xanthine, hypoxanthine, urate and allantoin that have been reported...
Topics
- ATP-Binding Cassette Transporters
- Animals
- Chromatography, Liquid
- Drosophila Proteins
- Drosophila melanogaster
- Female
- Fourier Analysis
- Male
- Mass Spectrometry
- Mutation