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Article

Metabolomic analysis of oxidative stress: Superoxide dismutase mutation and paraquat induced stress in Drosophila melanogaster.

Free radical biology & medicine - 1 Dec 2017

Doran Marney L, Knee Jose M, Wang Nan, Rzezniczak Teresa Z, Parkes Tony L, Li Liang, Merritt Thomas J S

Abstract excerpt

Oxidative stress results in substantial biochemical and physiological perturbations in essentially all organisms. To determine the broad metabolic effects of oxidative stress, we have quantified the response in Drosophila melanogaster to both genetically and environmentally derived oxidative stress. Flies were challenged with loss of Superoxide dismutase activity or chronic or acute exposure to the oxidizing...

Read the complete abstract on PubMed

Topics

Amines
Animals
Animals, Genetically Modified
Carboxylic Acids
Chromatography, Liquid
Drosophila melanogaster

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Isotope Labeling

Male

Metabolic Networks and Pathways

Metabolome

Mutation

Oxidative Stress

Paraquat

Phenols

Porphyrins

Principal Component Analysis

Superoxide Dismutase

Tandem Mass Spectrometry

Source

Identifiers

PMID: 29031835
DOI: 10.1016/j.freeradbiomed.2017.10.011

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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