Mapping point mutations in the Drosophila rosy locus using denaturing gradient gel blots.

doi:10.1093/genetics/127.1.139

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Article

Mapping point mutations in the Drosophila rosy locus using denaturing gradient gel blots.

Genetics - 1 Jan 1991

Gray M, Charpentier A, Walsh K, Wu P, Bender W

Abstract excerpt

Mutations within the rosy locus of Drosophila were mapped using blots of genomic DNA fragments separated on denaturing gradient gels. DNA sequence differences between otherwise identical small rosy DNA fragments were detected among the mutants as mobility shifts on the blots. Mutations were mapped to within a few hundred base pairs of rosy sequence in 100 of 130 mutants tested--a 77% detection rate. The sequence...

Topics

Animals
Base Sequence
Blotting, Southern
Chromosome Mapping
Cloning, Molecular
DNA
DNA Mutational Analysis
Drosophila melanogaster
Electrophoresis, Polyacrylamide Gel
Gene Expression
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutagens

Mutation

Nucleic Acid Denaturation

Nucleic Acid Hybridization

Protein Biosynthesis

RNA Processing, Post-Transcriptional

Xanthine Dehydrogenase

Source

Open in PubMed Open full text

Identifiers

PMID: 1901817
DOI: 10.1093/genetics/127.1.139
PMCID: PMC1204299

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1901817-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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