Article
Urate-null rosy mutants of Drosophila melanogaster are hypersensitive to oxygen stress.
Proceedings of the National Academy of Sciences of the United States of America - 15 May 1992
Hilliker A J, Duyf B, Evans D, Phillips J P
Abstract excerpt
It has been proposed that uric acid is an important scavenger of deleterious oxygen radicals in biological systems [Ames, B. N., Cathcart, R., Schwiers, E. & Hochstein, P. (1981) Proc. Natl. Acad. Sci. USA 78, 6858-6852]. We report here an in vivo investigation of the oxygen defense role of uric...
Topics
- Animals
- Antioxidants
- Crosses, Genetic
- Dose-Response Relationship, Radiation
- Drosophila melanogaster
- Female
- Free Radical Scavengers
- Genes
- Larva
- Male
- Mutation
- Oxygen
- Paraquat
- Radiation, Ionizing
- Superoxide Dismutase
- Superoxides
- Uric Acid
- Xanthine Dehydrogenase