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Article

Urate-null rosy mutants of Drosophila melanogaster are hypersensitive to oxygen stress.

Proceedings of the National Academy of Sciences of the United States of America - 15 May 1992

Hilliker A J, Duyf B, Evans D, Phillips J P

Abstract excerpt

It has been proposed that uric acid is an important scavenger of deleterious oxygen radicals in biological systems [Ames, B. N., Cathcart, R., Schwiers, E. & Hochstein, P. (1981) Proc. Natl. Acad. Sci. USA 78, 6858-6852]. We report here an in vivo investigation of the oxygen defense role of uric acid through an analysis of mutants of the rosy (ry) gene of Drosophila melanogaster. The ry gene is the structural...

Read the complete abstract on PubMed

Topics

Animals
Antioxidants
Crosses, Genetic
Dose-Response Relationship, Radiation
Drosophila melanogaster
Female

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Free Radical Scavengers

Genes

Larva

Male

Mutation

Oxygen

Paraquat

Radiation, Ionizing

Superoxide Dismutase

Superoxides

Uric Acid

Xanthine Dehydrogenase

Source

Open in PubMed Open full text

Identifiers

PMID: 1316606
DOI: 10.1073/pnas.89.10.4343
PMCID: PMC49078

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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