Article
Inactivation of Burkholderia pseudomallei bsaQ results in decreased invasion efficiency and delayed escape of bacteria from endocytic vesicles.
Archives of microbiology - 1 Dec 2008
Muangsombut Veerachat, Suparak Supaporn, Pumirat Pornpan, Damnin Suwat, Vattanaviboon Paiboon, Thongboonkerd Visith, Korbsrisate Sunee
Abstract excerpt
Burkholderia pseudomallei, an infectious Gram-negative bacterium, is the causative pathogen of melioidosis. In the present study, a B. pseudomallei strain with mutation in the bsaQ gene, encoding a structural component of the type III secretion system (T3SS), was constructed. This bsaQ mutation caused a marked decrease in secretion of BopE effector and BipD translocator proteins into culture supernatant. The B....
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