Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Manipulating the metazoan mitochondrial genome with targeted restriction enzymes.

Science (New York, N.Y.) - 25 Jul 2008

Xu Hong, DeLuca Steven Z, O'Farrell Patrick H

Abstract excerpt

High copy number and random segregation confound genetic analysis of the mitochondrial genome. We developed an efficient selection for heritable mitochondrial genome (mtDNA) mutations in Drosophila, thereby enhancing a metazoan model for study of mitochondrial genetics and mutations causing human mitochondrial disease. Targeting a restriction enzyme to mitochondria in the germline compromised fertility, but...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Deoxyribonucleases, Type II Site-Specific
Share to DNA Restriction Enzymes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genome, Insect

Share to Genome, Mitochondrial

Share to Infertility, Male

Share to Muscular Dystrophy, Animal

Share to Spermatogenesis

Source

Open in PubMed Open full text

Identifiers

PMID: 18653897
DOI: 10.1126/science.1160226
PMCID: PMC2754248

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Manipulating the metazoan mitochondrial genome with targeted restriction enzymes.PMID 18653897Read ↗

A Genome-wide Screen Reveals that Reducing Mitochondrial DNA Polymerase Can Promote Elimination of Deleterious Mitochondrial Mutations.Semantic proximity Read ↗

Avoiding Extinction: Recent Advances in Understanding Mechanisms of Mitochondrial DNA Purifying Selection in the Germline.Semantic proximity Read ↗

Tools for editing the mammalian mitochondrial genome.Semantic proximity Read ↗

Transmission of mitochondrial mutations and action of purifying selection in Drosophila melanogaster.Semantic proximity Read ↗

Mitochondrial curation for the next generation.Semantic proximity Read ↗

Manipulation of mitochondrial genes and mtDNA heteroplasmy.Semantic proximity Read ↗

A structure-selective endonuclease drives uniparental mitochondrial DNA inheritanceSemantic proximity Read ↗

The use of mitochondria-targeted endonucleases to manipulate mtDNA.Semantic proximity Read ↗

Selective elimination of mitochondrial mutations in the germline by genome editing.Semantic proximity Read ↗

Mitigation of the age-dependent decline in mitochondrial genome integritySemantic proximity Read ↗

Mitigation of age-dependent accumulation of defective mitochondrial genomes.Semantic proximity Read ↗

Construction of heteroplasmic mice containing two mitochondrial DNA genotypes by micromanipulation of single-cell embryos.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.