Article
Antisense ribosomal siRNAs inhibit RNA polymerase I-directed transcription in C. elegans.
Nucleic acids research - 20 Sept 2021
Liao Shimiao, Chen Xiangyang, Xu Ting, Jin Qile, Xu Zongxiu, Xu Demin, Zhou Xufei, Zhu Chengming, Guang Shouhong, Feng Xuezhu
Abstract excerpt
Eukaryotic cells express a wide variety of endogenous small regulatory RNAs that function in the nucleus. We previously found that erroneous rRNAs induce the generation of antisense ribosomal siRNAs (risiRNAs) which silence the expression of rRNAs via the nuclear RNAi defective (Nrde) pathway. To further understand the biological roles and mechanisms of this class of small regulatory RNAs, we conducted forward...
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