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Article

Determination of a quantitative relationship between hepatic CYP3A51/3 and CYP3A4 expression for use in the prediction of metabolic clearance in virtual populations.

Biopharmaceutics & drug disposition - 1 Nov 2010

Barter Z E, Perrett H F, Yeo K Rowland, Allorge D, Lennard M S, Rostami-Hodjegan A

Abstract excerpt

The creation of virtual populations allows the estimation of pharmacokinetic parameters, such as metabolic clearance in extreme individuals rather than the 'average human'. Prediction of variability in metabolic clearance within genetically diverse populations relies on understanding the covariation in the expression of enzymes. A number of statistically significant positive correlations have been observed in the...

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Source

Identifiers

PMID: 21104927
DOI: 10.1002/bdd.732

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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