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Article

In vitro studies on the metabolism of trabectedin (YONDELIS) in monkey and man, including human CYP reaction phenotyping.

Biochemical pharmacology - 15 May 2009

Vermeir Marc, Hemeryck Alex, Cuyckens Filip, Francesch Andres, Bockx Marc, Van Houdt Jos, Steemans Kathleen, Mannens Geert, Avilés Pablo, De Coster Roland

Abstract excerpt

Trabectedin (YONDELIS) is a potent anticancer agent which was recently approved in Europe for the treatment of soft tissue sarcoma. The drug is currently also in clinical development for the treatment of ovarian carcinoma. In vitro experiments were conducted to investigate the hepatic metabolism of [(14)C]trabectedin in Cynomolgus monkey and human liver subcellular fractions. The biotransformation of trabectedin...

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Identifiers

PMID: 19426702
DOI: 10.1016/j.bcp.2009.02.020

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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