Article
Genome-wide association study of rheumatoid arthritis in the Spanish population: KLF12 as a risk locus for rheumatoid arthritis susceptibility.
Arthritis and rheumatism - 1 Aug 2008
Julià Antonio, Ballina Javier, Cañete Juan D, Balsa Alejandro, Tornero-Molina Jesus, Naranjo Antonio, Alperi-López Mercedes, Erra Alba, Pascual-Salcedo Dora, Barceló Pere, Camps Jordi, Marsal Sara
Abstract excerpt
OBJECTIVE: To identify new genes associated with susceptibility to rheumatoid arthritis (RA), using a 2-stage genome-wide association study. METHODS: Following a liability-based study design, we analyzed 317,503 single-nucleotide polymorphisms (SNPs) in 400 patients with RA and 400 control subjects. We selected a group of candidate SNPs for replication in an independent group of 410 patients with RA and 394...
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