Article
ATP negatively regulates the initiator protein of Vibrio cholerae chromosome II replication.
Proceedings of the National Academy of Sciences of the United States of America - 29 Jul 2008
Duigou Stéphane, Yamaichi Yoshiharu, Waldor Matthew K
Abstract excerpt
Vibrio cholerae, the agent of cholera, has two circular chromosomes. In bacteria that contain a single chromosome, initiation of chromosome DNA replication is mediated by DnaA, a AAA+ ATPase that unwinds the origin of replication. There is little knowledge regarding initiation of chromosome replication in bacteria with more than one chromosome. Here, we purified V. cholerae DnaA and RctB, which have been...
Topics
- Adenosine Diphosphate
- Adenosine Triphosphate
- Bacterial Proteins
- Chromosomes, Bacterial
- DNA Replication
- DNA-Binding Proteins
- Dose-Response Relationship, Drug
- Gene Expression Regulation, Bacterial
- Genes, Bacterial
- Hydrolysis
- Models, Genetic
- Mutation
- Replication Origin
- Vibrio cholerae