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Article

Model system to evaluate the effect of ampD mutations on AmpC-mediated beta-lactam resistance.

Antimicrobial agents and chemotherapy - 1 Jun 2006

Schmidtke Amber J, Hanson Nancy D

Abstract excerpt

Mutations within the structural gene of ampD can lead to AmpC overproduction and increases in beta-lactam MICs in organisms with an inducible ampC. However, identification of mutations alone cannot predict the impact that those mutations have on AmpD function. Therefore, a model system was designed to determine the effect of ampD mutations on ceftazidime MICs using an AmpD(-) mutant Escherichia coli strain which...

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Identifiers

PMID: 16723562
DOI: 10.1128/AAC.01458-05
PMCID: PMC1479098

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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