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Article

Requirement of the Pseudomonas aeruginosa CbrA sensor kinase for full virulence in a murine acute lung infection model.

Infection and immunity - 1 Mar 2014

Yeung Amy T Y, Janot Laure, Pena Olga M, Neidig Anke, Kukavica-Ibrulj Irena, Hilchie Ashley, Levesque Roger C, Overhage Joerg, Hancock Robert E W

Abstract excerpt

Pseudomonas aeruginosa is an opportunistic pathogen that is a major cause of respiratory tract and other nosocomial infections. The sensor kinase CbrA is a central regulator of carbon and nitrogen metabolism and in vitro also regulates virulence-related processes in P. aeruginosa. Here, we investigated the role of CbrA in two murine models of infection. In both peritoneal infections in leukopenic mice and lung...

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Identifiers

PMID: 24379284
DOI: 10.1128/IAI.01527-13
PMCID: PMC3957987

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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