Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Shared genetic susceptibility of type 1 (insulin-dependent) and type 2 (non-insulin-dependent) diabetes mellitus: contributions of HLA and haptoglobin.

Diabetologia - 1 May 1991

Rich S S, Panter S S, Goetz F C, Hedlund B, Barbosa J

Abstract excerpt

Epidemiologic data suggest that having a parent with Type 2 (non-insulin-dependent) diabetes mellitus increases the risk for Type 1 (insulin-dependent) diabetes in siblings of a Type 1 diabetes proband. This increase in risk is consistent with a shared genetic susceptibility between Type 1 diabetes and Type 2 diabetes. We contrast genetic risk factors in three sets of families, consisting of (1) a single Type 1...

Topics

Adult
Child
Diabetes Mellitus, Type 1
Diabetes Mellitus, Type 2
Disease Susceptibility
Female
Genetic Predisposition to Disease
HLA Antigens
Haptoglobins
Humans
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Risk Factors

Source

Identifiers

PMID: 1864490
DOI: 10.1007/BF00405008

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1864490-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Shared genetic susceptibility of type 1 (insulin-dependent) and type 2 (non-insulin-dependent) diabetes mellitus: contributions of HLA and haptoglobin.PMID 1864490Read ↗

HLA Class II Allele Analyses Implicate Common Genetic Components in Type 1 and Non-Insulin-Treated Type 2 Diabetes.Semantic proximity Read ↗

A genetic explanation for the rising incidence of type 1 diabetes, a polygenic disease.Semantic proximity Read ↗

Increased and decreased relative risk for non-insulin-dependent diabetes mellitus conferred by HLA class II and by CD4 alleles.Semantic proximity Read ↗

Complex interaction between HLA DR and DQ in conferring risk for childhood type 1 diabetes.Semantic proximity Read ↗

Three generations of autoimmune diabetes: an extended family study.Semantic proximity Read ↗

Analysis of families at risk for insulin-dependent diabetes mellitus reveals that HLA antigens influence progression to clinical disease.Semantic proximity Read ↗

IDDM2-VNTR-encoded susceptibility to type 1 diabetes: dominant protection and parental transmission of alleles of the insulin gene-linked minisatellite locus.Semantic proximity Read ↗

Possible human leukocyte antigen-mediated genetic interaction between type 1 and type 2 Diabetes.Semantic proximity Read ↗

Humoral beta-cell autoimmunity in relation to HLA-defined disease susceptibility in preclinical and clinical type 1 diabetes.Semantic proximity Read ↗

Do non-insulin-dependent diabetes mellitus (NIDDM) and insulin-dependent diabetes mellitus (IDDM) share genetic susceptibility loci? An analysis of putative IDDM susceptibility regions in familial NIDDM.Semantic proximity Read ↗

Genetic susceptibility for insulin-dependent diabetes mellitus in Caucasians revisited: the importance of diabetes registries in disclosing interactions between HLA-DQ- and insulin gene-linked risk. Belgian Diabetes Registry.Semantic proximity Read ↗

5' insulin gene polymorphism confers risk to IDDM independently of HLA class II susceptibility.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.