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Article

Diabetic pdx1-mutant zebrafish show conserved responses to nutrient overload and anti-glycemic treatment.

Scientific reports - 18 Sept 2015

Kimmel Robin A, Dobler Stefan, Schmitner Nicole, Walsen Tanja, Freudenblum Julia, Meyer Dirk

Abstract excerpt

Diabetes mellitus is characterized by disrupted glucose homeostasis due to loss or dysfunction of insulin-producing beta cells. In this work, we characterize pancreatic islet development and function in zebrafish mutant for pdx1, a gene which in humans is linked to genetic forms of diabetes and is associated with increased susceptibility to Type 2 diabetes. Pdx1 mutant zebrafish have the key diabetic features of...

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Identifiers

PMID: 26384018
DOI: 10.1038/srep14241
PMCID: PMC4585597

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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